Protein polyufmylation

Across TCGA patient cohorts, RNA activity of the Protein polyufmylation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL24, AGK, and BAX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polyufmylation activity versus KLHL24 in LUAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLHL24 →	-0.326	-0.103	.004	.004	3	4
UCEC	AGK →	-0.300	-0.123	.008	.005	3	4
OV	BAX →	-0.405	-0.116	.002	.001	3	3
BRCA	PSMF1 →	+0.451	+0.231	<.001	<.001	3	3
GBM	MIR193B →	-0.708	-0.077	.001	.006	3	3
BRCA	RNU2-13P →	+0.943	+0.174	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990564 vs KLHL24 — LUAD

Explore this scatter interactively →