Protein polyufmylation

Across TCGA cell cohorts, RNA activity of the Protein polyufmylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPP, HEATR1, and SLPI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPP grouped by Protein polyufmylation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LPP →	+1.136	+1.216	.007	<.001	3	6
BONE	HEATR1 →	-1.384	-1.898	.002	<.001	3	5
STOMACH	SLPI →	+4.437	+2.044	<.001	<.001	3	5
PANCREAS	PSMB8 →	+1.660	+0.815	.002	.007	3	5
STOMACH	MEX3A →	-2.171	-1.745	<.001	<.001	3	5
SOFT_TISSUE	SLC16A3 →	+5.359	+1.656	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPP by Protein polyufmylation activity — LUNG_SCLC

Explore this box plot interactively →