Protein polyufmylation

Across TCGA cell cohorts, RNA activity of the Protein polyufmylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFS1, LRMDA, and RARS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polyufmylation activity versus NDUFS1 in LUNG_NSCLC_LUSC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NDUFS1 →	+1.085	+0.463	.002	<.001	3	7
LUNG_NSCLC_LUAD	LRMDA →	+1.316	+0.161	.001	.005	3	7
LUNG_NSCLC_LUSC	RARS2 →	+0.794	+0.309	.004	.005	3	6
STOMACH	FBXL4 →	+0.611	+0.379	<.001	<.001	3	6
LARGE_INTESTINE	UQCRB →	+0.551	+0.166	<.001	.001	3	6
BLOOD_Lymphoma	ENSA →	+0.618	+0.137	.006	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990564 vs NDUFS1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →