Neuron projection maintenance

Across TCGA cell cohorts, RNA activity of the Neuron projection maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM62, SCARB1, and CDC25B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection maintenance activity versus TRIM62 in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TRIM62 →	+0.873	+1.212	.002	<.001	3	4
OESOPHAGUS	SCARB1 →	-0.924	-0.888	.006	.008	3	4
BLOOD_Leukemia	CDC25B →	+1.103	+0.998	.001	.001	3	4
BLOOD_Leukemia	FAAH →	-1.229	-0.731	.004	.002	2	5
BLOOD_Leukemia	ADORA2A →	+1.371	+1.013	.004	<.001	3	4
OESOPHAGUS	ULBP3 →	-0.785	-1.117	.004	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990535 vs TRIM62 — BLOOD_Lymphoma

Explore this scatter interactively →