Dense core granule exocytosis

Across TCGA patient cohorts, RNA activity of the Dense core granule exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCND3, ADH1B, and ATP8A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dense core granule exocytosis activity versus KCND3 in BRCA (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KCND3 →	+1.051	+0.495	.003	.006	3	5
GBM	ADH1B →	+0.173	+1.070	.004	<.001	3	5
GBM	ATP8A1 →	+1.453	+0.991	<.001	<.001	3	4
BRCA	RFC4 →	-0.774	-0.700	<.001	<.001	3	4
BRCA	CENPW →	-1.173	-0.525	<.001	.002	3	4
GBM	RAP1GAP →	+1.300	+1.081	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990504 vs KCND3 — BRCA

Explore this scatter interactively →