Cellular response to brain-derived neurotrophic factor stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to brain-derived neurotrophic factor stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, CBX8, and HNRNPLL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to brain-derived neurotrophic factor stimulus activity versus SMC2 in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMC2 →	+0.429	+0.144	<.001	<.001	3	6
HNSC	CBX8 →	+0.404	+0.151	<.001	<.001	3	6
HNSC	HNRNPLL →	+0.239	+0.144	<.001	<.001	3	6
UCEC	SH3GLB1 →	-0.290	-0.126	<.001	.004	3	6
LSCC	EHD4 →	-0.248	-0.164	<.001	<.001	3	6
GBM	RASSF5 →	-0.549	-0.135	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990416 vs SMC2 — HNSC

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