Cellular response to brain-derived neurotrophic factor stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to brain-derived neurotrophic factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF2K, SERPINE1, and SIAE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to brain-derived neurotrophic factor stimulus activity versus EEF2K in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EEF2K →	+0.411	+0.764	<.001	<.001	3	6
CCRCC	SERPINE1 →	-1.213	-0.496	.001	.002	3	5
LUAD	SIAE →	+0.615	+0.506	<.001	.002	3	4
UCEC	MT3 →	-0.697	-0.631	.006	<.001	2	5
BRCA	THUMPD1 →	+0.566	+0.752	.001	<.001	3	4
LUAD	ALG1 →	+0.293	+0.602	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990416 vs EEF2K — UCEC

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