Embryonic brain development

Across TCGA patient cohorts, RNA activity of the Embryonic brain development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCTN2, DHRS13, and MORN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic brain development activity versus TCTN2 in LUAD (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TCTN2 →	+0.501	+0.147	.001	.006	3	5
LSCC	DHRS13 →	+0.425	+0.165	.005	.002	3	4
UCEC	MORN3 →	+0.529	+0.183	.003	.009	2	5
BRCA	TSEN2 →	+0.423	+0.180	.002	<.001	3	4
LSCC	PIMREG →	+0.666	+0.188	.002	<.001	3	4
OV	GPR84 →	-0.814	-0.167	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990403 vs TCTN2 — LUAD

Explore this scatter interactively →