Embryonic brain development

Across TCGA cell cohorts, RNA activity of the Embryonic brain development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC8, CTSO, and IL1R2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXOSC8 grouped by Embryonic brain development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EXOSC8 →	+0.901	+0.275	.003	.006	3	4
LUNG_NSCLC_LUSC	CTSO →	-1.088	-0.182	.006	.009	3	4
PANCREAS	IL1R2 →	+1.464	+0.242	.001	.005	3	4
LIVER	SMC2 →	-1.190	-0.466	.008	.004	3	4
LIVER	NEURL1B →	-1.915	-0.425	<.001	.002	3	4
BLOOD_Myeloma	PCYOX1L →	-1.490	-0.393	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXOSC8 by Embryonic brain development activity — BLOOD_Leukemia

Explore this box plot interactively →