Cellular response to insulin-like growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to insulin-like growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPGS2, CSF1, and MESD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPGS2 grouped by Cellular response to insulin-like growth factor stimulus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TPGS2 →	-0.683	-1.162	.002	.003	2	5
BLOOD_Lymphoma	CSF1 →	+0.627	+0.251	.002	.003	3	4
BLOOD_Leukemia	MESD →	+0.509	+0.230	.001	.006	3	4
STOMACH	LACTB →	+1.508	+1.287	.001	.001	3	4
LARGE_INTESTINE	SPATA7 →	-0.630	-0.284	.001	.005	3	3
BLOOD_Myeloma	WDR38 →	-0.087	-1.609	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPGS2 by Cellular response to insulin-like growth factor stimulus activity — OVARY

Explore this box plot interactively →