Cellular response to insulin-like growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to insulin-like growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM7, NTHL1, and IL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to insulin-like growth factor stimulus activity versus PDLIM7 in LIVER (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PDLIM7 →	-2.226	-0.239	.001	<.001	3	5
SOFT_TISSUE	NTHL1 →	+0.586	+0.298	.002	.006	3	4
SOFT_TISSUE	IL11 →	-2.657	-0.302	.002	.005	3	4
LARGE_INTESTINE	HRH1 →	-0.596	-0.265	<.001	.006	3	4
LIVER	ZNF365 →	-2.527	-0.407	<.001	.008	3	4
LUNG_SCLC	RTN4RL1 →	+0.927	+0.179	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990314 vs PDLIM7 — LIVER

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