Cellular response to leucine starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to leucine starvation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD54L, RRBP1, and ALDH1L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to leucine starvation activity versus RAD54L in LUNG_NSCLC_LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAD54L →	-0.770	-0.662	<.001	.003	2	4
KIDNEY	RRBP1 →	+1.657	+0.364	.006	.006	3	3
LUNG_NSCLC_LUAD	ALDH1L2 →	+1.543	+0.816	.002	.007	3	3
LUNG_SCLC	CEP68 →	-0.876	-1.074	.005	.005	3	3
KIDNEY	OTUD3 →	+1.124	+0.450	.005	.008	3	3
KIDNEY	FBXW11 →	+0.680	+0.527	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990253 vs RAD54L — LUNG_NSCLC_LUAD

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