Protein localization to site of double-strand break

Across TCGA cell cohorts, RNA activity of the Protein localization to site of double-strand break pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UIMC1, TAF9, and HNRNPCL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UIMC1 grouped by Protein localization to site of double-strand break-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UIMC1 →	-1.102	-0.328	.002	.009	3	5
OVARY	TAF9 →	-0.922	-0.154	.002	.006	3	5
SOFT_TISSUE	HNRNPCL1 →	-0.168	-0.264	<.001	.003	3	4
LARGE_INTESTINE	DAP →	-0.830	-0.268	.001	.001	3	4
LARGE_INTESTINE	NDEL1 →	-0.580	-0.251	.001	.001	3	4
LARGE_INTESTINE	SH2D2A →	+1.160	+0.275	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UIMC1 by Protein localization to site of double-strand break activity — BLOOD_Lymphoma

Explore this box plot interactively →