Neuron projection extension

Across TCGA patient cohorts, RNA activity of the Neuron projection extension pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL2, KIAA0513, and HSD17B6, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection extension activity versus MYL2 in COAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYL2 →	+0.102	+0.907	.002	<.001	3	2
COAD	KIAA0513 →	+0.472	+0.848	.005	.009	3	2
OV	HSD17B6 →	+2.383	+0.126	.009	.006	3	2
COAD	PHF5CP →	+0.335	+0.729	.001	.005	3	2
OV	KLF8 →	+1.422	+0.192	.001	.001	3	2
OV	GNAL →	+0.960	+0.183	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990138 vs MYL2 — COAD

Explore this scatter interactively →