Negative regulation of calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3R2, PPP3CC, and PPP3CA, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP3R2 grouped by Negative regulation of calcium ion import across plasma membrane-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PPP3R2 →	-0.322	-1.476	.002	.001	3	13
PANCREAS	PPP3CC →	-0.185	-0.891	.002	.006	3	8
CNS	PPP3CA →	-0.169	-1.180	<.001	<.001	3	6
OVARY	TUBB4A →	+0.191	+1.001	<.001	.003	3	5
OESOPHAGUS	SNW1 →	+0.237	+0.568	<.001	.007	3	5
BREAST	PPP3R1 →	-0.264	-1.084	.003	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP3R2 by Negative regulation of calcium ion import across plasma membrane activity — LIVER

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