Negative regulation of calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC123, SAE1, and TBC1D15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC123 grouped by Negative regulation of calcium ion import across plasma membrane-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CDC123 →	+0.578	+1.181	.005	.002	3	4
LUNG_NSCLC_LUSC	SAE1 →	+0.993	+1.292	.005	<.001	3	4
LUNG_NSCLC_LUAD	TBC1D15 →	-0.411	-0.586	<.001	.003	3	3
LARGE_INTESTINE	XK →	-0.830	-0.621	.007	.006	3	3
LUNG_NSCLC_LUAD	SLC9A7 →	+1.305	+0.811	.009	.006	3	3
BLOOD_Myeloma	HCFC1R1 →	+0.644	+1.252	.007	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC123 by Negative regulation of calcium ion import across plasma membrane activity — LUNG_SCLC

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