Positive regulation of gonad development

Across TCGA patient cohorts, RNA activity of the Positive regulation of gonad development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMPK2, CX3CR1, and ATP6V1E1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gonad development activity versus CMPK2 in PDAC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CMPK2 →	+0.973	+0.889	<.001	<.001	3	4
GBM	CX3CR1 →	-0.809	-0.324	.001	.004	3	4
LUAD	ATP6V1E1 →	-0.368	-0.847	<.001	.001	3	3
GBM	TMEM144 →	-0.910	-0.354	.005	.002	3	3
LSCC	RBP7 →	-0.685	-0.599	.007	.001	3	3
HNSC	LRPAP1 →	+0.398	+0.547	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905941 vs CMPK2 — PDAC

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