Regulation of gonad development

Across TCGA patient cohorts, RNA activity of the Regulation of gonad development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EZH2_T367, LIN54_S635, and PBK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gonad development activity versus EZH2_T367 in OV (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EZH2_T367 →	-1.093	-0.042	.005	.005	3	6
OV	LIN54_S635 →	-0.926	-0.102	.001	<.001	3	6
LUAD	PBK →	-0.524	-0.073	<.001	<.001	3	6
LUAD	NCAPH →	-0.609	-0.097	<.001	<.001	3	6
LUAD	TOP2A →	-0.905	-0.079	<.001	<.001	3	5
LUAD	ECT2_T359 →	-1.488	-0.090	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905939 vs EZH2_T367 — OV

Explore this scatter interactively →