Regulation of calcium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QTNF1, ABCG2, and KMT5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1QTNF1 grouped by Regulation of calcium ion export across plasma membrane-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C1QTNF1 →	+1.556	+0.900	.005	.002	3	4
BLOOD_Leukemia	ABCG2 →	+1.198	+1.037	.003	.006	3	4
OESOPHAGUS	KMT5A →	+0.630	+1.095	.003	.007	2	4
OESOPHAGUS	L1CAM →	+3.705	+1.655	<.001	<.001	3	3
BONE	HPX →	+0.990	+1.377	.006	.001	3	3
BONE	PTK2B →	+1.306	+1.377	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1QTNF1 by Regulation of calcium ion export across plasma membrane activity — OVARY

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