Negative regulation of amyloid fibril formation

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid fibril formation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPINDOC, NT5DC2, and LRRC47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPINDOC grouped by Negative regulation of amyloid fibril formation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPINDOC →	+1.073	+0.463	<.001	<.001	3	5
STOMACH	NT5DC2 →	+1.316	+0.425	.002	.003	3	5
BLOOD_Leukemia	LRRC47 →	+0.580	+0.953	.006	<.001	3	5
BLOOD_Leukemia	CENPW →	+0.974	+0.866	.001	.004	3	4
PANCREAS	TMEM200B →	+1.498	+0.954	.001	.006	3	4
BREAST	RPL41 →	-0.634	-0.721	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPINDOC by Negative regulation of amyloid fibril formation activity — STOMACH

Explore this box plot interactively →