Regulation of amyloid fibril formation

Across TCGA cell cohorts, RNA activity of the Regulation of amyloid fibril formation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL21A, SLC25A11, and RCBTB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid fibril formation activity versus METTL21A in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	METTL21A →	+0.922	+1.264	.002	.006	3	6
BONE	SLC25A11 →	+0.983	+0.504	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	RCBTB1 →	+0.609	+1.364	.004	.003	2	6
LARGE_INTESTINE	CCT7 →	+0.465	+0.781	.005	.007	3	5
BLOOD_Lymphoma	RABEP1 →	+0.821	+0.172	.002	.005	3	5
BONE	DNPH1 →	+2.177	+0.413	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905906 vs METTL21A — UPPER_AERODIGESTIVE_TRACT

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