Regulation of response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS31, MARK1, and ZNF287, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to endoplasmic reticulum stress activity versus MRPS31 in HNSC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MRPS31 →	-0.463	-0.146	.002	.001	3	6
LSCC	MARK1 →	-0.715	-0.183	.005	<.001	3	6
HNSC	ZNF287 →	-0.561	-0.132	.001	.006	3	6
HNSC	BRSK1 →	-0.511	-0.119	.008	.003	3	6
HNSC	ZNF853 →	-0.750	-0.187	.001	<.001	3	6
PDAC	ROPN1B →	-0.275	-0.173	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905897 vs MRPS31 — HNSC

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