Regulation of postsynaptic density organization

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic density organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXO1, BLM, and HLA-A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density organization activity versus EXO1 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EXO1 →	+0.687	+0.262	<.001	.002	3	5
LSCC	BLM →	+0.690	+0.232	.002	.009	3	5
LSCC	HLA-A →	-0.778	-0.189	<.001	.001	3	4
LSCC	HLA-B →	-0.771	-0.242	<.001	.008	3	4
COAD	FBLL1 →	+0.271	+0.405	.004	.002	3	4
UCEC	NUDT19P5 →	-0.692	-0.381	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905874 vs EXO1 — LSCC

Explore this scatter interactively →