Positive regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the Positive regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEATR3, EDC4, and SORBS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of 3'-UTR-mediated mRNA stabilization activity versus HEATR3 in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HEATR3 →	+0.379	+0.076	<.001	<.001	3	6
GBM	EDC4 →	+0.188	+0.076	.005	<.001	2	7
COAD	SORBS1 →	-0.468	-0.045	<.001	<.001	3	5
COAD	SYNPO2 →	-0.858	-0.066	<.001	<.001	3	5
COAD	DNAJA3 →	+0.392	+0.061	<.001	.002	2	6
COAD	FYCO1_S196 →	-0.424	-0.065	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905870 vs HEATR3 — LUAD

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