Positive regulation of chromosome condensation

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromosome condensation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPD2, AGAP6, and GRIK5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCAPD2 grouped by Positive regulation of chromosome condensation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NCAPD2 →	-0.238	-0.203	.001	.002	3	9
KIDNEY	AGAP6 →	-0.244	-0.210	.006	.003	3	5
PANCREAS	GRIK5 →	+0.111	+0.067	.003	.006	3	4
SOFT_TISSUE	NCAPD3 →	-0.528	-0.244	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SLC25A43 →	-0.180	-0.228	<.001	<.001	3	4
LUNG_NSCLC_LUAD	NRL →	+0.120	+0.114	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCAPD2 by Positive regulation of chromosome condensation activity — BLOOD_Leukemia

Explore this box plot interactively →