Regulation of anaphase-promoting complex-dependent catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of anaphase-promoting complex-dependent catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB, KIFC1, and ORC6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of anaphase-promoting complex-dependent catabolic process activity versus TUBB in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TUBB →	+0.711	+0.422	<.001	.008	3	9
GBM	KIFC1 →	+1.142	+0.437	<.001	<.001	3	9
BRCA	ORC6 →	+0.848	+0.733	<.001	<.001	3	9
BRCA	JPT1 →	+1.053	+0.751	<.001	<.001	3	8
LSCC	RAD51AP1 →	+0.935	+0.670	<.001	.002	3	8
LSCC	CDCA3 →	+0.952	+0.651	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905784 vs TUBB — HNSC

Explore this scatter interactively →