Regulation of anaphase-promoting complex-dependent catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of anaphase-promoting complex-dependent catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC20_T70, MCM5, and HJURP_S412, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of anaphase-promoting complex-dependent catabolic process activity versus CDC20_T70 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDC20_T70 →	+1.265	+1.009	<.001	<.001	3	8
GBM	MCM5 →	+0.678	+0.483	<.001	<.001	3	8
CCRCC	HJURP_S412 →	+1.480	+0.601	<.001	.003	3	7
BRCA	MKI67 →	+0.994	+0.830	<.001	<.001	3	7
LSCC	ORC6_T195 →	+1.077	+0.827	<.001	<.001	3	7
LSCC	RRP36_S73 →	+0.867	+0.795	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905784 vs CDC20_T70 — LUAD

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