Regulation of anaphase-promoting complex-dependent catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of anaphase-promoting complex-dependent catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK2, C3orf38, and DMPK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of anaphase-promoting complex-dependent catabolic process activity versus CDK2 in BLOOD_Leukemia (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDK2 →	+0.895	+0.702	.005	.005	3	4
BLOOD_Leukemia	C3orf38 →	+0.455	+0.509	<.001	.003	3	4
BLOOD_Lymphoma	DMPK →	+0.873	+0.381	<.001	.003	3	4
CNS	PARD6G →	+1.089	+0.342	.002	.001	3	4
BLOOD_Leukemia	PTPRK →	+2.742	+0.543	<.001	.006	2	4
BLOOD_Lymphoma	GRK3 →	-2.151	-0.366	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905784 vs CDK2 — BLOOD_Leukemia

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