Positive regulation of membrane permeability

Across TCGA cell cohorts, RNA activity of the Positive regulation of membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP50, BBS7, and GINS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of membrane permeability activity versus NUP50 in OVARY (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NUP50 →	-0.979	-0.272	.003	.002	2	6
OVARY	BBS7 →	-0.737	-0.281	.006	<.001	2	5
OVARY	GINS3 →	-1.121	-0.259	<.001	.004	3	4
BREAST	LARGE2 →	+1.488	+0.214	.005	.006	3	4
LUNG_SCLC	DOCK1 →	-1.206	-0.149	.004	.009	3	4
SKIN	CMTM6 →	-0.582	-0.288	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905710 vs NUP50 — OVARY

Explore this scatter interactively →