Negative regulation of membrane permeability

Across TCGA cell cohorts, RNA activity of the Negative regulation of membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, TJP2, and EPCAM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TJP3 grouped by Negative regulation of membrane permeability-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TJP3 →	+2.059	+1.397	.001	<.001	3	5
LUNG_NSCLC_LUAD	TJP2 →	+1.088	+0.874	.006	.002	2	6
LUNG_NSCLC_LUSC	EPCAM →	+3.348	+1.377	.003	.004	3	5
PANCREAS	PLEKHA7 →	+2.178	+1.535	.008	.001	3	5
BLOOD_Leukemia	FUT1 →	+3.098	+1.691	<.001	<.001	3	5
BLOOD_Leukemia	BCL2L1 →	+2.248	+1.670	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TJP3 by Negative regulation of membrane permeability activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →