Negative regulation of membrane permeability

Across TCGA cell cohorts, RNA activity of the Negative regulation of membrane permeability pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP7, LRRIQ4, and KRTAP5-4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GIMAP7 grouped by Negative regulation of membrane permeability-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GIMAP7 →	-0.286	-0.204	.001	.001	3	5
BLOOD_Leukemia	LRRIQ4 →	+0.200	+0.111	.007	<.001	3	4
LUNG_NSCLC_LUAD	KRTAP5-4 →	-0.102	-0.115	.003	.001	3	4
PANCREAS	HSD17B10 →	-0.252	-0.159	<.001	.001	3	4
SKIN	SLC7A11 →	+0.149	+0.083	.001	.002	3	4
LIVER	PPP1R12A →	+0.336	+0.164	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GIMAP7 by Negative regulation of membrane permeability activity — SOFT_TISSUE

Explore this box plot interactively →