Negative regulation of membrane permeability

Across TCGA cell cohorts, RNA activity of the Negative regulation of membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAA2, SCN9A, and FRAT2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of membrane permeability activity versus ACAA2 in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACAA2 →	+2.452	+0.305	.003	<.001	2	12
BLOOD_Myeloma	SCN9A →	-2.108	-0.254	<.001	.003	2	6
BLOOD_Myeloma	FRAT2 →	+1.132	+0.238	<.001	.006	3	5
STOMACH	NDEL1 →	-1.120	-0.269	.007	.007	3	5
LUNG_NSCLC_LUAD	PSMD12 →	-0.533	-0.170	.004	.004	2	6
STOMACH	SNX2 →	-1.058	-0.285	.002	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905709 vs ACAA2 — STOMACH

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