Regulation of lysosome organization

Across TCGA patient cohorts, RNA activity of the Regulation of lysosome organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MC1R, FAM120AOS, and TBCAP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome organization activity versus MC1R in HNSC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MC1R →	+0.547	+0.531	.005	.003	3	3
PDAC	FAM120AOS →	-0.228	-0.320	.001	.001	3	3
LSCC	TBCAP1 →	-0.244	-0.339	.003	.007	3	3
CCRCC	POU5F1P4 →	-0.255	-0.605	.007	.003	3	2
CCRCC	RPL23AP10 →	-0.285	-0.633	.005	.001	3	2
HNSC	TRIM14 →	+0.796	+0.551	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905671 vs MC1R — HNSC

Explore this scatter interactively →