Regulation of protein localization to endosome

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to endosome pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFDN6, LONP2, and TCTA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFDN6 grouped by Regulation of protein localization to endosome-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PFDN6 →	-0.879	-1.327	.007	.006	3	6
OESOPHAGUS	LONP2 →	+0.566	+0.801	.007	.006	3	4
CNS	TCTA →	+0.911	+0.794	.001	.007	3	4
BONE	ROM1 →	+0.929	+1.746	.001	<.001	3	4
OVARY	LHPP →	-1.224	-0.865	<.001	.001	3	4
PANCREAS	PUF60 →	-0.589	-1.061	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFDN6 by Regulation of protein localization to endosome activity — LUNG_NSCLC_LUSC

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