Regulation of calcium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNG2, KCTD12, and MS4A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion import across plasma membrane activity versus GNG2 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GNG2 →	+0.451	+0.063	.002	.005	3	7
UCEC	KCTD12 →	+0.445	+0.099	.003	<.001	3	7
LSCC	MS4A1 →	+0.970	+0.116	<.001	<.001	3	7
COAD	EPB41L3 →	+0.282	+0.035	.008	.009	3	7
LSCC	FLI1 →	+0.448	+0.129	<.001	<.001	3	7
LSCC	FOLR2 →	+0.530	+0.106	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905664 vs GNG2 — GBM

Explore this scatter interactively →