Regulation of calcium ion import across plasma membrane

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of calcium ion import across plasma membrane pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Regulation of calcium ion import across plasma membrane pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and LUAD, show the opposite pattern, with higher activity associated with better survival.

READ, LIHC, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.342	0.838	<.001	70	view →
LIHC	DFS	Tertile	All	0.648	0.465	<.001	56	view →
OV	OS	Median	All	0.646	0.722	.011	54	view →
LUAD	DFS	Median	All	0.831	0.750	.004	51	view →
UVM	DFS	Quartile	All	0.218	0.904	.006	44	view →
SCLC	OS	Tertile	All	0.270	0.952	.002	42	view →
ACC	OS	Tertile	III,IV	0.150	0.715	<.001	32	view →
MESO	OS	Quartile	III,IV	0.461	0.732	.006	29	view →
KIRP	OS	Median	II,III,IV	0.166	0.782	.004	24	view →
UCS	OS	Median	III,IV	0.398	0.745	.007	20	view →
THCA	DFS	Median	IV	0.915	0.660	.009	11	view →
KIRC	DFS	Median	All	0.922	0.815	.038	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:1905664–READ (DFS)

Open the READ breakdown →