Regulation of calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC37A3, CDK5R2, and RERE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion import across plasma membrane activity versus LRRC37A3 in BONE (Pearson r = -0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LRRC37A3 →	-2.330	-1.850	.006	<.001	3	4
BREAST	CDK5R2 →	+0.326	+1.719	.004	<.001	3	4
BONE	RERE →	-1.372	-1.692	.006	<.001	3	3
BLOOD_Leukemia	RALB →	+2.068	+1.737	.001	<.001	2	4
BONE	PRSS12 →	+2.816	+1.850	<.001	<.001	3	3
BREAST	UBE2S →	+1.636	+1.646	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905664 vs LRRC37A3 — BONE

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