Regulation of artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM3, CSRNP3, and CDH11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of artery morphogenesis activity versus JAM3 in CCRCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	JAM3 →	+0.771	+0.718	<.001	<.001	3	6
HNSC	CSRNP3 →	+0.754	+0.554	<.001	.001	3	5
HNSC	CDH11 →	+0.596	+0.427	.001	.002	3	5
HNSC	OLFML1 →	+0.740	+0.996	<.001	<.001	3	5
PDAC	NGF →	+0.376	+0.276	<.001	.004	3	4
HNSC	SNED1 →	+0.727	+0.696	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905651 vs JAM3 — CCRCC

Explore this scatter interactively →