Regulation of artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM8, ACTBL2, and SLCO3A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCM8 grouped by Regulation of artery morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MCM8 →	+0.736	+1.437	.001	.002	3	5
BREAST	ACTBL2 →	-0.461	-1.044	.009	<.001	3	4
BREAST	SLCO3A1 →	-1.326	-0.896	.009	.003	3	4
LARGE_INTESTINE	HLA-F →	-2.540	-1.171	.001	.002	3	4
BLOOD_Lymphoma	AKT1 →	+0.961	+2.078	<.001	<.001	3	4
BLOOD_Lymphoma	LCN2 →	-1.605	-2.289	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCM8 by Regulation of artery morphogenesis activity — LIVER

Explore this box plot interactively →