Positive regulation of blood-brain barrier permeability

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood-brain barrier permeability pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OCLN, P3H1, and PCDH1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood-brain barrier permeability activity versus OCLN in HNSC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OCLN →	+0.710	+0.086	<.001	<.001	3	8
OV	P3H1 →	-0.630	-0.089	<.001	<.001	3	8
LSCC	PCDH1 →	+0.475	+0.073	<.001	<.001	3	8
OV	TJP3_S112 →	+1.274	+0.088	<.001	.001	3	7
LSCC	TJP3_S378 →	+0.889	+0.077	<.001	<.001	3	7
UCEC	CRTAP →	-0.383	-0.094	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905605 vs OCLN — HNSC

Explore this scatter interactively →