Positive regulation of blood-brain barrier permeability

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood-brain barrier permeability pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, F2RL1, and C3orf52, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood-brain barrier permeability activity versus TJP2 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TJP2 →	+0.896	+1.130	.003	<.001	2	6
LUNG_NSCLC_LUAD	F2RL1 →	+1.523	+0.653	.005	.003	3	4
LUNG_NSCLC_LUAD	C3orf52 →	+1.059	+0.598	<.001	.003	3	3
LUNG_NSCLC_LUAD	MAB21L4 →	+2.273	+0.615	.001	.004	3	3
STOMACH	ZNF771 →	-0.824	-1.421	.001	.003	3	3
LUNG_NSCLC_LUAD	LY75 →	+1.636	+0.587	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905605 vs TJP2 — BREAST

Explore this scatter interactively →