Regulation of blood-brain barrier permeability

Across TCGA patient cohorts, RNA activity of the Regulation of blood-brain barrier permeability pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01943, PRR15L, and FMO5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood-brain barrier permeability activity versus LINC01943 in PDAC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LINC01943 →	-0.462	-0.879	.001	.001	3	6
OV	PRR15L →	+1.137	+0.494	.004	.003	3	6
LUAD	FMO5 →	+0.855	+0.563	.009	.002	2	6
PDAC	ANXA9 →	+0.513	+0.745	.005	.007	3	5
BRCA	ATP8B1 →	+1.314	+0.519	<.001	.001	3	5
LUAD	PPP2R5A →	+0.354	+0.583	.009	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905603 vs LINC01943 — PDAC

Explore this scatter interactively →