Regulation of blood-brain barrier permeability

Across TCGA cell cohorts, RNA activity of the Regulation of blood-brain barrier permeability pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDYL, ZNF230, and PPTC7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDYL grouped by Regulation of blood-brain barrier permeability-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDYL →	-0.730	-1.008	.001	.003	3	4
LUNG_NSCLC_LUAD	ZNF230 →	+0.415	+1.013	.005	.001	3	4
BLOOD_Leukemia	PPTC7 →	-0.748	-0.796	.001	.005	3	4
BLOOD_Leukemia	HSD17B11 →	+1.804	+1.447	<.001	<.001	3	4
BLOOD_Leukemia	HDAC7 →	-1.790	-1.062	<.001	.001	3	4
LUNG_SCLC	SCAF8 →	+0.616	+0.856	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDYL by Regulation of blood-brain barrier permeability activity — BLOOD_Leukemia

Explore this box plot interactively →