Negative regulation of vascular endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular endothelial cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC32A1, HEXIM1, and ACY3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC32A1 grouped by Negative regulation of vascular endothelial cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC32A1 →	-0.171	-0.983	.004	.008	3	4
BREAST	HEXIM1 →	+0.133	+0.935	<.001	<.001	3	4
SOFT_TISSUE	ACY3 →	+0.320	+1.800	.001	<.001	3	3
SOFT_TISSUE	SCAMP2 →	-0.137	-1.582	.006	.001	3	3
BONE	BRCA1 →	-0.263	-1.626	.002	.002	3	3
LARGE_INTESTINE	RBM11 →	-0.238	-0.897	.007	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC32A1 by Negative regulation of vascular endothelial cell proliferation activity — BREAST

Explore this box plot interactively →