Regulation of macrophage migration

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF14, LSP1, and EIF3H, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage migration activity versus TNFSF14 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFSF14 →	+0.719	+0.204	.002	.002	3	6
BRCA	LSP1 →	+0.536	+0.143	.007	.009	3	5
BRCA	EIF3H →	-0.376	-0.124	<.001	.003	3	5
BRCA	KCNQ1 →	+0.553	+0.143	.002	.004	3	5
GBM	FBLN5 →	+0.895	+0.237	<.001	<.001	3	5
OV	PIK3R5 →	+0.757	+0.241	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905521 vs TNFSF14 — GBM

Explore this scatter interactively →