Positive regulation of fertilization

Across TCGA patient cohorts, RNA activity of the Positive regulation of fertilization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DIDO1, MYO9B, and CSTF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fertilization activity versus DIDO1 in COAD (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DIDO1 →	-0.196	-0.058	.006	.002	3	5
LSCC	MYO9B →	+0.173	+0.079	.002	.003	3	5
UCEC	CSTF3 →	-0.183	-0.087	.003	.004	3	5
GBM	RCOR3_T376 →	-0.419	-0.081	.005	.001	3	4
GBM	SFPQ →	-0.184	-0.051	<.001	<.001	3	4
GBM	SMARCE1 →	-0.216	-0.053	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905516 vs DIDO1 — COAD

Explore this scatter interactively →