Positive regulation of fertilization

Across TCGA cell cohorts, RNA activity of the Positive regulation of fertilization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A4, ZNF300, and AMIGO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC1A4 grouped by Positive regulation of fertilization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC1A4 →	+1.795	+1.690	.004	<.001	3	4
LUNG_NSCLC_LUSC	ZNF300 →	+2.530	+1.266	.003	.003	3	4
BREAST	AMIGO2 →	-2.228	-0.907	<.001	<.001	3	3
KIDNEY	GAL3ST3 →	+0.290	+1.516	.009	.005	3	3
KIDNEY	CDRT4 →	+1.442	+1.830	.002	<.001	3	3
OESOPHAGUS	TRAPPC4 →	+0.579	+1.774	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC1A4 by Positive regulation of fertilization activity — LIVER

Explore this box plot interactively →