Non-motile cilium assembly

Across TCGA patient cohorts, RNA activity of the Non-motile cilium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKRD22, IFT74, and WDR54, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-motile cilium assembly activity versus ANKRD22 in HNSC (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANKRD22 →	-0.504	-0.058	<.001	<.001	3	8
BRCA	IFT74 →	+0.382	+0.029	<.001	<.001	3	7
UCEC	WDR54 →	+0.412	+0.043	<.001	.002	3	7
OV	IFT122 →	+0.353	+0.040	.001	.003	3	7
BRCA	ARL3 →	+0.395	+0.032	<.001	<.001	3	7
HNSC	TP53BP1_T922 →	+0.373	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905515 vs ANKRD22 — HNSC

Explore this scatter interactively →