Non-motile cilium assembly

Across TCGA patient cohorts, RNA activity of the Non-motile cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNJ12, MKNK1-AS1, and RN7SL430P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-motile cilium assembly activity versus KCNJ12 in CCRCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KCNJ12 →	-0.460	-0.829	.001	<.001	3	3
CCRCC	MKNK1-AS1 →	-0.228	-0.506	<.001	<.001	3	3
BRCA	RN7SL430P →	-0.105	-0.780	.001	<.001	3	3
GBM	WDR59 →	-0.305	-0.651	<.001	<.001	3	3
GBM	LINC02648 →	-0.266	-0.425	.002	.006	3	3
GBM	LINC01776 →	+0.833	+0.485	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905515 vs KCNJ12 — CCRCC

Explore this scatter interactively →