Non-motile cilium assembly

Across TCGA cell cohorts, RNA activity of the Non-motile cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBD3, SAP30, and ZNF664, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-motile cilium assembly activity versus MBD3 in SOFT_TISSUE (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MBD3 →	+0.926	+0.264	.009	.007	2	7
LARGE_INTESTINE	SAP30 →	+1.200	+0.219	<.001	<.001	3	5
BLOOD_Leukemia	ZNF664 →	+1.083	+0.329	<.001	<.001	3	5
SOFT_TISSUE	ZNF491 →	+1.156	+0.343	.004	<.001	3	4
SOFT_TISSUE	ZNF253 →	+2.063	+0.321	.002	<.001	3	4
SOFT_TISSUE	CCDC134 →	+1.202	+0.273	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905515 vs MBD3 — SOFT_TISSUE

Explore this scatter interactively →